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Colon Cancer Pathophysiology. Polyp histology is critical for determining malignant potential. Conventional adenomas by the conventional adenoma to carcinoma sequence and serrated adenomas according to the serrated adenoma to carcinoma theory. It is a multifactorial disease process with etiology encompassing genetic factors environmental exposures including diet and. Colon cancer is a type of cancer that begins in the large intestine colon.
Colon cancer is the most common type of gastrointestinal cancer. Conventional adenomas by the conventional adenoma to carcinoma sequence and serrated adenomas according to the serrated adenoma to carcinoma theory. The first step in carcinogenesis is the development of specific types of neoplastic polyps in colonic mucosa. Colon cancer is believed to arise from two types of precursor polyps via two distinct pathways. Polyp histology is critical for determining malignant potential. Pathophysiology clinical presentation and management of colon cancer.
Colon cancer is a type of cancer that begins in the large intestine colon.
Colon cancer is the best understood complex multistep cancer in terms of molecular genetics. Pathophysiology of colorectal cancer. It is a multifactorial disease process with etiology encompassing genetic factors environmental exposures including diet and. The two common histologic types are hyperplastic and adenomatous. Colon cancer typically affects older adults though it can happen at any age. Crc results from a stepwise accumulation of genetic defects and clonal proliferation of mutated colonic epithelial cells in an adenomacarcinoma transformation sequence of normal colonic mucosa a protuberant growth known as polyp or adenoma fig.