28
Mar
Guillain Barre Syndrome Etiology. The etiology and pathogenesis remain largely enigmatic and the syndrome results in death or severe disability in 9 17 of cases despite immunotherapy. Guillain barre syndrome gbs is a reactive self limited monophasic disease triggered by a preceding bacterial or viral infection. In gbs a demyelinating process occurs that is characterized by damage to this sheath. This leads to weakness numbness.
In guillain barre syndrome your immune system which usually attacks only invading organisms begins attacking the nerves. While gbs comes on rapidly over days to weeks and the person usually recovers other disorders develop slowly and can linger or recur. Gbs has also been linked to underlying systemic diseases certain malignancies surgery pregnancy trauma severe infection and tissue transplantation bone marrow and organs. The syndrome can affect the nerves that control muscle movement as well as those that transmit feelings of pain temperature and touch. The etiology and pathogenesis remain largely enigmatic and the syndrome results in death or severe disability in 9 17 of cases despite immunotherapy. This can result in muscle weakness and loss of sensation in the legs and or arms.
In gbs a demyelinating process occurs that is characterized by damage to this sheath.
In aidp the most common form of guillain barre syndrome in the u s the nerves protective covering myelin sheath is damaged. It is believed that the event triggers an abnormal immune response in which the body produces antibodies specific immune particles that attack neurons or the material lining the neurons. Guillain barre syndrome may also occur after covid 19 infection. Guillain barre syndrome causes peripheral nerve cells have axons coated by myelin sheaths that play a role in accelerating the delivery of electrical impulses. Guillain barré syndrome is a rare disease representing the most frequent cause of acute flaccid symmetrical weakness of the limbs and areflexia usually reaching its peak within a month. This leads to weakness numbness.