20
Feb
Lovenox Heparin Induced Thrombocytopenia. If someone receiving heparin develops new or w. Heparin induced thrombocytopenia is the development of thrombocytopenia due to the administration of various forms of heparin an anticoagulant. Heparin induced thrombocytopenia hit is a life threatening immune response to heparin and its derivatives that is associated with a high risk of thromboembolic complications. The diagnosis of hit was established in 126 patients by platelet aggregometry with uh 1 u ml.
Heparin induced thrombocytopenia hit is a serious antibody mediated reaction resulting from irreversible aggregation of platelets. Heparin induced thrombocytopenia hit is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 pf4 and heparin. To determine whether low molecular weight heparin lmwh can be an alternative to unfractionated heparin uh for patients with heparin induced thrombocytopenia syndrome hit. Heparin induced thrombocytopenia hit is a life threatening immune response to heparin and its derivatives that is associated with a high risk of thromboembolic complications. Pathogenic antibodies to pf4 heparin bind and activate cellular fcγriia on platelets and monocytes to propagate a hypercoagulable state culminating in life threatening thrombosis. Our objective was to determine and compare the incidences of hit in surgical and medical patients receiving thromboprophylaxis with either ufh or lmwh.
To determine whether low molecular weight heparin lmwh can be an alternative to unfractionated heparin uh for patients with heparin induced thrombocytopenia syndrome hit.
A risk that could increase with delay in diagnosis or increase in heparin dose to treat unrecognized hit associated thrombosis or through use of warfarin. Hit predisposes to thrombosis because platelets release microparticles that activate thrombin thereby leading to thrombosis. Heparin induced thrombocytopenia is the development of thrombocytopenia due to the administration of various forms of heparin an anticoagulant. Hit is caused by the formation of abnormal antibodies that activate platelets. The risk of heparin induced thrombocytopenia hit associated with low molecular weight heparin lmwh for treatment of superficial vein thrombosis svt is uncertain. Heparin induced thrombocytopenia hit is an uncommon but potentially devastating complication of anticoagulation with unfractionated heparin ufh or low molecular weight heparin lmwh.