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Pathophysiology Of Biliary Atresia. Biliary atresia ba is a congenital biliary disorder which is characterized by an absence or severe deficiency of the extrahepatic biliary tree. Jaundice that lasts beyond 3 weeks of age may be the first sign of biliary atresia. Infants with biliary atresia typically develop jaundice by 3 to 6 weeks of age. It is hypothesized that an event occurring during fetal life or at the time of birth may trigger the disease such as.
Untreated the resulting cholestasis leads to progressive conjugated hyperbilirubinemia cirrhosis and hepatic failure. Indeed there have been cases of identical twins where only one child has the disease. Cells within the liver produce liquid called bile. From the liver it moves through a network of tube like structures called bile ducts to the small intestine where it helps the body break down and absorb food. Biliary atresia is a rare disease of the liver and bile ducts that occurs in infants. It is hypothesized that an event occurring during fetal life or at the time of birth may trigger the disease such as.
Infants with biliary atresia typically develop jaundice by 3 to 6 weeks of age.
Bile helps to digest fat. Bile can t flow into the intestine so bile builds up in the liver and damages it. Infants with biliary atresia may also have pale yellow gray or white stools. Biliary atresia is a serious liver disorder that occurs before or shortly after birth when a baby s bile ducts the tubes that carry bile from the liver become blocked. It is hypothesized that an event occurring during fetal life or at the time of birth may trigger the disease such as. Jaundice that lasts beyond 3 weeks of age may be the first sign of biliary atresia.